Systemic Lupus erythematosus (SLE) is an autoimmune, multisystemic disease characterized by numerous patterns of clinical and immunological manifestations. One of the distinctive markers is the production of autoantibodies, especially to nuclear antigens that include double chain DNA (ds-DNA), histones and soluble ribonucleoproteins (RNP) and Sm antigen. Numerous factors contribute to the formation of these and these include: the loss of tolerance of B and T cells, an increase in concentration and an abnormal presentation of autoantibodies (e.g. nucleosomes), and defects in the clereance of apoptotic cells among others. The variability in these events influences the nature and organic commitment in SLE.