The scavenging of singlet oxygen and other reactive oxygen species by DNA origami nanostructures is explored in an antimicrobial photodynamic therapy setting. While genomic double-stranded DNA is a poor quencher of singlet oxygen, folding it into DNA origami nanostructures results in a drastically increased singlet oxygen quenching efficiency. DNA origami nanostructures thus have great potential to alleviate the oxidative stress caused by singlet oxygen in diverse therapeutic settings. More information can be found in the Research Article by A. Keller and co-workers (DOI: 10.1002/chem.202402057).