This chapter is concerned with the study of entrepreneurial ecosystems (EEs) in Central and Eastern European (CEE) contexts. It summarizes the key findings of over 15 years of study of EEs in such places and draws together insights gained from empirical work, which helps us to push forward the theorizing of EEs by incorporating the experiences of regional and national contexts usually overlooked in the mainstream literature. This chapter contextualizes EEs in CEEs as peripheral when considered on the international scale, and thus broadens the discussion to more general insights about peripheral EEs, which have thus far been largely overlooked in research, suggesting that insights from these contexts can fill in some blind spots around migrant and informal or necessity entrepreneurship in particular.