Objective: To evaluate, in a healthcare worker population with COVID-19, the severity of the disease and the impact of an outpatient Phase II exercise-based cardiopulmonary rehabilitation program (CPRP) on functional capacity, function measured by the Post-COVID-19 Functional Status (PCFS) scale, and job reinstatement.Materials and method: A quasi-experimental study was conducted, involving 48 healthcare workers with COVID-19.Severity of infection, cardiopulmonary function, and PCFS were assessed at the beginning and end.The CPRP included three weekly sessions of personalized continuous and interval exercises lasting 20 to 60 minutes, with an intensity of 60 to 80% of maximum heart rate over one month.Results: There were 19 moderate cases and 29 severe cases.The average age was 54 (SD: 15.5) years, and 41.7% were employees, 47.9% were obese, and 39.6% were hypertensive.A total of 68.8% had typical pneumonia, 29.2% experienced post-traumatic stress, 43.8% had depressive syndrome, and 50% had anxiety disorders.Cardiopulmonary capacity improved from New York Heart Association (NYHA) Class II (5.7 SD: 1.2) to NYHA Class I (8.2 SD: 2.0).Independence in activities of daily living (PCFS scale) improved, and 36 patients returned to work.There were no severe complications.Conclusion: This study demonstrated a positive impact of the CPRP on cardiopulmonary function and independence in daily and instrumental activities among healthcare workers with COVID-19, with 75% returning to their regular duties.