Objective: This study aimed to investigate the effects of orthosis, and additional nerve and tendon gliding exercises (NTGE) on median nerve morphology and functional status in patients with mild-to-moderate carpal tunnel syndrome (CTS) and to compare the effectiveness of proposed treatments.Methods: Twenty-seven wrists of 19 patients with mild-to-moderate CTS were included in the study.They were randomized into three groups: neutral wrist orthosis alone (n=8), the combination of the orthosis with nerve gliding exercises (NGE) (n=10), and the combination of the orthosis with nerve/tendon gliding exercises (n=9).The cross-sectional area (CSA) of the median nerve (ultrasonography) and functional status (Boston carpal tunnel syndrome questionnaire and patient-specific functional scale) were evaluated at baseline and after six weeks of treatment.Results: While the functional status of all groups improved significantly (p<0.05), the CSA of the median nerve significantly decreased in the combination of the orthosis with NGE group (p<0.05).However, there were no significant differences between the treatment groups in relation to the improvement in the intraneural edema and the functional status (p<0.05). ÖZAmaç: Bu çalışmanın amacı, hafif-orta şiddette karpal tünel sendromlu (KTS) hastalarda ortez ile orteze ek sinir ve tendon kayma egzersizlerinin (STKE) medyan sinir morfolojisi ve fonksiyonel durum üzerindeki etkilerini araştırmak ve önerilen tedavilerin etkinliğini karşılaştırmaktır.Yöntemler: Hafif-orta derecede KTS'li 19 hastanın 27 el bileği çalışmaya dahil edildi.Hastalar üç gruba ayrıldı: nötral el bileği ortezi grubu (n=8), ortez ile SKE grubu (n=10) ve ortez ile STKE (n=9).Medyan sinirin enine kesit alanı (ultrasonografi) ve hastaların fonksiyonel durumu (Boston karpal tünel sendromu anketi ve hastaya özgü fonksiyonel