PURPOSE Pain is the second most frequent symptom reported in patients with cancer, due to its multidimensional characteristics involving cognitive and central sensitization mechanisms that require other intervention strategies. Modern pain neuroscience has improved the understanding of pain, including the role of sensitization in pain intervention processes. In this regard, the use of educational modalities has been recommended. In this sense, neuroscience education (PNE) is an intervention that provides elements of the neurophysiology of pain that are transferred to the patient through examples or metaphors. The objective is to examine the effectiveness of PNE on pain and biopsychosocial variables in comparison with conventional management. METHODS A single-blind controlled clinical trial will be carried out (Trial registration number NCT05581784), which requires 82 adults with the presence of oncological pain due to prostate cancer in men and uterine and breast cancer in women in stages III and IV. A baseline evaluation will be generated considering pain and biopsychosocial variables. After that, randomization will be carried out where two groups will work: one corresponding to pain neuroscience education (PNE), where the participants will carry out one weekly session until completing 9 educational sessions each with a duration of 30 minutes; the second group (control) will not receive the educational intervention; and the two groups will have the elements of conventional management estimated by the treating physician. The post-intervention evaluation will be carried out after 10 weeks for both groups. Within the statistical processing, analysis will be considered per protocol and by intention to treat according to the variables evaluated. RESULTS This study is in the process of recruiting patients according to the sample inclusion criteria. CONCLUSION It is expected that the intervention based on education in pain neuroscience will have greater effectiveness in pain modulation processes compared to patients who did not receive the intervention; it is expected that the educational content generated can be used in patients with these characteristics.