The Serranía de la Lindosa in the Colombian Amazon hosts one of the most spectacular global rock art traditions. Painted in vibrant ochre pigments, the artwork depicts abstract and figurative designs – including a high diversity of animal motifs – and holds key information for understanding how Amazonians made sense of their world. We compare a zooarchaeological assemblage with painted depictions of animals at the Cerro Azul site, and utilise relevant ethnographies and ethnohistories. A lack of direct proportional relationships between the animal representation in the art and zooarchaeological remains alludes to the complex socio-cultural interconnection between Amazonian communities and their ritualised environments. We discuss the benefits and limitations of quantitative categorisation and explore Indigenous ontologies, highlighting Amazonian perspectives on human-animal relationships.