To elucidate the anatomic course of the lateral pectoral nerve (LPN) relative to superficial landmarks and identify a technique to reach the sensory branches with a needle. The course and location of the LPN were identified about the associated superficial anatomy in 10 fresh human cadaveric shoulders. Using these external anatomical landmarks, a calibrated spinal needle was used to identify a consistent approach that positioned the needle tip at the lateral pectoral nerve proximal to the sensory branch origin. Different glenohumeral abduction angles were evaluated. The LPN branched from the lateral cord at the junction of the anterior division of the middle and upper trunks. The LPN and sensory branches were identified consistently medial to, and slightly deep to, the coracoid. The coracoid tip was a significant superficial anatomic reference point. These sensory branches of the LPN were identified in 9 out of 10 specimens. The LPN sensory branches were identified medial and deep to the coracoid. A needle is introduced immediately medial to the coracoid, aiming towards the sternoclavicular joint at a 30° angle and to a depth of 2.5 cm, consistently reaching these sensory branches. Shoulder movement consistent with beach chair or lateral decubitus positioning did not compromise this position. No vascular or other neurological structures were close to the needle. A needle can be reliably inserted into the region of the LPN and its sensory branches, allowing a sensory block of the lateral pectoral nerve.