The study aimed to conduct a systematic review of therapeutic treatments to cope with a love breakup from 1992 to 2023 in Spanish, English and Portuguese in EBSCO, PsycINFO, PubMed, Scopus, and Web of Science (WOS). Two independent researchers performed the searches and data extraction. Out of 156 records, 13 articles are included addressing treatments to cope with love breakups. Most of the studies found were in the United States and Iran and aimed to women. The studies showed a significant decrease in symptoms of depression and anxiety during the love breakup. Empirical evaluation of the efficacy of future interventions to deal with breakups is recommended, based on experimental designs in adolescents and young people of both sexes.