This research integrates physical, social, and economic aspects to address seismic vulnerability in the municipality of Toluca, Mexico. The objective is to design and implement a procedure that estimates seismic vulnerability at the urban block scale. The developed method combines physical and socio-economic dimensions to assess seismic vulnerability. The physical dimension includes susceptibility to seismic resonance, as well as the age and type of constructions, while the socio-economic dimension is based on the marginalization index. Mapping covers 7,807 urban blocks where five levels of vulnerability are identified, with 46.6% exhibiting severe and very severe levels. The resulting zoning is a robust tool for risk reduction, particularly for justifying the implementation of actions aimed at reducing vulnerability.