A systematic exploratory review was carried out to describe the influence of climate change on the health conditions of land transport drivers, both physical and mental. Additionally, actions for the prevention of these complications are described. For the review, several databases, such as Science Direct, MEDLINE, Springer, PubMed, Redalyc, EBSCO, SciELO, and Scopus, were examined. There was the need to extend the search timeframe from 5 years to 10 years. The studies found consisted mainly of review articles, showing an emphasis on public health and a high frequency of possible physical effects on the cardiovascular and respiratory systems. At the mental level, the presence of cases of anxiety, depression and stress were mentioned. As for alternatives for the prevention of these effects, the importance of creating public policies for health promotion and disease prevention was highlighted. It is important to increase scientific production in the field of occupational safety and health and applied studies.