Background and Objectives: By adapting a skeleton hierarchical multiphasic and anisotropic architecture, bone remodeling occurs when responding an external loading. Piezoelectric properties, allows to transform mechanical stress into electrical field, obviously promote fluid flow streaming generated potential (SGP) studied here under a process within a complex canaliculi microarchitecture. Containing ultrastructural features amplify the fluid flow-derived mechanical stimulus and variation in cells paracrine factors. Methods: Leading a biological, Multiphysics interactions simultaneously, we build a computational model, resulting in evolution of "mechano-piezoelectrical forces" enhancing the new concept of "Coupled SGP". The presence of piezoelectrical matrix, change the fluid electrical potential and kinetic energy around cells through coupled concept. The original fluid streaming potential found to be increased up to 80%. We based on the superpositions of electro-induction, due to emersed cells within environment of Extra Cellular Matrix (ECM).Results: An equivalent additional charge is generated, driving a significant change in Zeta potential, due to the surrounded piezoelectricity converted to additional electrical charge into Interstitial Fluid Flow (IFF). Calculating osteocyte signalization and evaluating the osteoblast Paracrines, when this excited by additional electrical force from coupled SGP.Conclusion: This study reveals how the governing flow orientation divert electromechanical force toward cells responses. We advance the concept of coupling Zeta potential, enhancing the remodeling regions located in forward direction of the governing flow by increasing coupled SGP. Showing how the inhomogeneous lacunas constellations may disrupt the flow energy spread and generate spinning topology in ECM upstream regions, causing drop of remodeling cells activities.