Abstract Background TEP (Totally ExtraPeritoneal) technique is used for inguinal hernia treatment. It is now considered a basic technique in minimally invasive abdominal wall surgery and the door to more complex procedures. In high volume centers this approach can be used for purposes other than reconstructive. Method We present the clinical case of a 44-year-old patient with a history of multiple lymph nodes located in the axilla and pelvic areas, with no pathologic histologic findings since 1992, after several surgical samplings (follicular lymphoid hyperplasia in all specimens). Bone marrow biopsy in 2020 highly suspected a non Hodgkin lymphoma, it did not correlate with periferal biopsy results, all of which rendered inconclusive results. In 2023, in image follow-up by PET-CT scan revealed a high PDF uptake (SUV 17,9) located in a bulky node (38 × 32 mm) in the right exernal iliac area. As a highly experienced surgical group in TEP hernioplasty, an endoscopic preperitoneal exploration and lymph node biopsy was indicated to avoid open surgery. Result An outpatient surgery was succesfuly performed. An en-bloc sample was obtained. There were no intraoperative or postoperative complications. Pathologic findings: Low-grade Non-Hodgkin Lymphoma IV-B IPI-2. Conclusion The Totally Extraperitoneal access can be used not only for inguinal hernioplasty but also for other indications such as a selective deep inguinal lymphadenectomy.