In patients with congenital heart disease, transcatheter pulmonary valve implantation is the treatment of choice in dysfunctional right ventricular outflow tracts (RVOT).The self-expandable Venus-P valve was approved recently for use in large native tracs.This study reports the experience of the first case of successful implantation of Venus-P pulmonary valve in Colombia.Ours was a 16-year-old patient with Tetralogy of Fallot, with complete correction at 11 months of life.The patient has severe pulmonary insufficiency and functional class deterioration.Cardiac catheterization was performed to place a 34X30 mm Venus-P valve, a procedure carried out without complications, evidencing significant improvement in the diastolic pressure of the pulmonary artery, without final gradient between the right ventricle and pulmonary artery.Reports exist of experiences in Venus-P valve implant globally with favorable results; percutaneous valve placement represents decreased procedure times and hospital stays.We believe percutaneous valve replacement in pulmonary position in native RVOTs is a possible and safe option to improve pulmonary insufficiency and right ventricular dysfunction in these types of patients.