The genus Hypolobocera Ortmann, 1897, is represented by 38 species and is distributed in the south-western Panama, Venezuela, Colombia, Ecuador, and Peru, including the twenty-two registered species for Colombia. We describe and illustrate a new species of Hypolobocera Ortmann, 1897 from the foothills of the Western Cordillera, Antioquia Department, Cauca River basin, Colombia, which increases in this country the number of Hypolobocera species to twenty-three. The species distribution of this genus covers an extensive area of the Colombian territory, including most of Colombia’s major river basins. We distinguished the new species from its congeners mainly by the third maxilliped, with an exopod that is 0.20 to 0.30 the length of ischium, and by the morphology of the first male gonopod, particularly by the shapes of the lateral and the mesial lobes and the outline of the apex. We include a key to species identification that uses the morphology of the first male gonopod.