Objective: Temporomandibular disorder (TMD), a musculoskeletal disease, especially when it becomes chronic, may result in functional limitation and disability. The aim of this study is to evaluate the relationship between functional limitation and disability with sociodemographic characteristics and clinical symptoms in patients with TMD. Material and Methods: This cross-sectional, clinical study was conducted on patients diagnosed with temporomandibular joint (TMJ) disorder according to the Diagnostic Criteria for TMDs (DC/TMD) in the oral and maxillofacial surgery clinic of a university. In clinical examination, the patients were evaluated in terms of pain, maximum mouth opening (MMO) and joint sounds (click, crepitus). Functional limitation was evaluated with Jaw Functional Limitation Scale-20 (JFLS-20), and disability status was evaluated with Temporomandibular Disability Index (TDI). Results: 381 TMD patients (318 females, 63 males) were included in the study. JFLS-20 and TDI scores significantly increased as participants' MMO decreased and TMJ pain level increased (p<0.001). Those with joint noise complaints such as clicking and crepitation had higher JFLS-20 and TDI scores than those without (p<0.001). In addition, a strong correlation was observed between the MMO, pain, values of the JFLS-20, and TDI scores. Conclusion: Clinical symptoms in TMD patients are closely related to functional limitation and disability. Worsening of clinical symptoms in TMD patients causes an increase in functional limitation and disability.