Plant-animal interactions are essential for the structure and functioning of ecosystems, especially in regions of high biodiversity such as the Colombian Andes. This study focuses on the networks of frugivorous interactions between birds and plants in two high-Andean forests in southwestern Colombia, aiming to analyze the structure of these networks and determine the factors influencing their configuration. Using systematic observations in the Puracé National Natural Park and a forest remnant in Totoró, interactions were recorded over a two-year period. Standardized sampling methods were employed to quantify 454 and 307 feeding events in Puracé and Totoró, respectively. The results indicated a low overall connectivity in both networks, although a high degree of nestedness was observed. Key species such as Miconia orcheotoma and Freziera canescens dominated the interactions, suggesting a significant influence of certain plant species on network structure due to their fruit abundance. At the network level, robustness showed that the networks could withstand species loss without collapsing, suggesting underlying stability despite low connectivity. In conclusion, this study highlights the importance of generalist plant species in maintaining the cohesion of frugivorous networks in Andean forests, providing stability against environmental or anthropogenic changes. These findings underline the need to conserve both bird species and frugivorous plant species to preserve the ecological functionality and ecosystem services provided by these critical ecosystems.