Edema is a frequent manifestation in patients with advanced diseases. There is a little research on it. The symptomatic impact it generates, the functional limitation, and the decreased quality of life are often underestimate in those affected patients. Many strategies for their management are employed, but the therapeutic response and tolerance are limited in patients with advanced diseases. We present the case of a patient with progressive retroperitoneal sarcoma who develops severe lower limb lymphedema of multifactorial etiology, refractory to treatment, in whom was performed subcutaneous lymphatic drainage with clinical improvement and impact on quality of life. Finally, there is a discussion of the topic and a review of the available literature on the presence of lymphedema in patients with cancer and the different available therapeutic options.