Purpose: Developmental epileptic encephalopathies (DEE) are a group of conditions featuring drug-resistant epilepsies and a large spectrum of comorbidities, which result in an enormous psychosocial burden. In the last decade, the use of vagus nerve stimulation (VNS) as adjuvant therapy for seizure control has been implemented. The purpose of this article is to collect evidence on the effectiveness of the use of VNS as adjuvant therapy in DEE