The Amazon, the world's largest rainforest covering more than 1·6 billion acres1World Wildlife FundAmazon facts.https://www.worldwildlife.org/places/amazonDate: 2023Date accessed: September 10, 2023Google Scholar extends across numerous South American nations—including Bolivia, Brazil, Colombia, Ecuador, French Guiana, Guyana, Peru, Suriname, and Venezuela.2World Wildlife FundLiving Amazon report 2022.https://www.worldwildlife.org/publications/living-amazon-report-2022Date: Nov 8, 2022Date accessed: October 1, 2023Google Scholar It plays a crucial part in climate stability by storing more than 150 000 billion tons of carbon and accounts for between 15% and 20% of the total freshwater discharge into the Atlantic.3Strand J Soares-Filho B Costa MH et al.Spatially explicit valuation of the Brazilian Amazon forest's ecosystem services.Nat Sustain. 2018; 1: 657-664Crossref Scopus (0) Google Scholar It is home to approximately 47 million people, including 2·2 million indigenous individuals.3Strand J Soares-Filho B Costa MH et al.Spatially explicit valuation of the Brazilian Amazon forest's ecosystem services.Nat Sustain. 2018; 1: 657-664Crossref Scopus (0) Google Scholar To these inhabitants, the Amazon provides a wide range of essential services and supplies, plays a pivotal role in regulating the local climate, purifying water sources, and supplying various edible and medicinal plants,4Gonzalez Daza W Muylaert RL Sobral-Souza T Lemes Landeiro V Malaria risk drivers in the Brazilian Amazon: land use-land cover interactions and biological diversity.Int J Environ Res Public Health. 2023; 206497Crossref PubMed Scopus (0) Google Scholar and serves as a protective barrier for its inhabitants from the spread of vector-borne diseases such as Zika and malaria.5MacDonald AJ Mordecai EA Amazon deforestation drives malaria transmission, and malaria burden reduces forest clearing.Proc Natl Acad Sci USA. 2019; 116: 22212-22218Crossref PubMed Scopus (126) Google Scholar Despite these crucial roles, the Amazon faces a state of existential crisis.3Strand J Soares-Filho B Costa MH et al.Spatially explicit valuation of the Brazilian Amazon forest's ecosystem services.Nat Sustain. 2018; 1: 657-664Crossref Scopus (0) Google Scholar Deforestation, wildfires, and environmental degradation pose grave threats to its biodiversity, with the surface and groundwater experiencing rising pollution. To address this threat, a regional perspective to better conceive integrated solutions for saving the Amazon has been proposed.6Peña-Claros M Nobre C A regional approach to save the Amazon.Science. 2023; 3811261Crossref PubMed Scopus (3) Google Scholar While this is a much needed and comprehensive approach, we argue that the safeguarding of human health should also become a key component of this solution, especially given that the wellbeing of Amazonian communities is essential for the preservation of the Amazon and that health promotion and disease protection could serve as an effective nudge to implement the integrated solutions. The people of the Amazon are encountering varied adverse public health effects. First, an ecosystem transformed by deforestation ensues a shift in spatial distributions, providing new breeding grounds for disease-carrying vectors, such as mosquitos. Additionally, an altered microclimate promoting greater vector survival, faster development and likelihood for the emergence of novel pathogens, and enhanced risks of antimicrobial resistance.7Lemos LN Pedrinho A de Vasconcelos AT Tsai SM Mendes LW Amazon deforestation enriches antibiotic resistance genes.Soil Biol Biochem. 2021; 153108110Crossref Scopus (17) Google Scholar Furthermore, increased population movement increases exposure to vector-borne diseases. Second, deforestation and wildfires substantially release particulate matter and greenhouse gases into the atmosphere, which causes respiratory issues, worsening conditions such as asthma, respiratory infections, and vascular and neoplastic conditions.8Reid CE Brauer M Johnston FH Jerrett M Balmes JR Elliott CT Critical review of health impacts of wildfire smoke exposure.Environ Health Perspect. 2016; 124: 1334-1343Crossref PubMed Scopus (682) Google Scholar Third, deforestation and mining operations tend to intensify chemical contamination, acid mine drainage, and habitat destruction causing health risks to aquatic ecosystems and humans. These risks include spreading waterborne diseases such as diarrhoea and cholera, heavy metal poisoning from mercury, lead, and arsenic, skin conditions, and limited access to clean water.9Passos CJ Mergler D Human mercury exposure and adverse health effects in the Amazon: a review.Cad Saude Publica. 2008; 24: s503-s520Crossref PubMed Google Scholar Fourth, the gradual disappearance of traditional fruits, nuts, and other edible resources are likely to result in food and nutritional insecurity. The introduction of industrial agriculture practices such as biofuel crops and cattle ranching can further exacerbate food insecurity among local inhabitants.10Shanley P Luz L The impacts of forest degradation on medicinal plant use and implications for health care in eastern Amazonia.Bioscience. 2003; 53: 573-584Crossref Scopus (143) Google Scholar Fifth, the environmental crisis in the Amazon is increasing the burden of stress and anxiety disorders among the local population. For example, deforestation and similar environmentally harmful activities are illegal and can heighten feelings of insecurity and vulnerability within affected communities. Finally, the ongoing climate crisis in the Amazon is likely to impact major social determinants of health such as migration, economic stability, education, safety, and availability of local traditional medicine. The health challenges in the Amazon, as outlined earlier, are complexly interconnected (figure). Hence, preserving the Amazon's sustainability and wellbeing necessitates a systems thinking-based comprehensive strategy, as isolated solutions could prove insufficient to sustain the region's resilience and could potentially worsen other health-related issues. To address effectively the Amazon crisis, a comprehensive approach, involving multiple stakeholders at local, national, and regional levels in South America (and perhaps beyond), is urgently needed. Therefore, considering the overwhelming human health implications and highlighting the health argument to reinforce the regional-wide efforts will be critical for adaption and scale up of co-beneficial health adaptation strategies. In particular, such health-related strategies could involve the developing of: locally relevant, replicable, nature-based measures to enhance health resiliency; greater public awareness regarding consequences to Amazon deforestation, such as beef, soy, gold, and other ore; a whole-of-society approach for primary health care; community-based telemedicine networks to facilitate remote health-care consultations among isolated communities; transdisciplinary research to characterise the links between deforestation, climate change, and health to take context-specific and scalable solutions; and mobilising local advocacy groups, non-governmental organisations, and civil society to push for policy reform and acquire increased political commitments. This way, by importantly acknowledging the interconnected link between environmental degradation and human health consequences, we could act more effectively towards preserving the Amazon, the wellbeing of its communities, and the planet by extension. We declare no conflicts of interest. RC and BT contributed equally.