Objective: Establish the association between the D-Dimer levels and pulmonary embolism (PE) in CT pulmonary angiogram (CTPA) in patients with COVID 19 in critical care. Methodology: Case Control study in patients with diagnosis of COVID 19 in three critical care units during 2021 in Medellin. All patients had CTPA as a diagnostic method for PE. Results: There were 135 cases and 136 controls, mean age 60 years old (IQ 51-70), 74.2 % were men. 39% had high blood pressure. Segmentary PE was found in 65.2%, lobar PE in 19.3% and 15.6% in the right or left pulmonary artery. We found that it is more likely to have PE if the D-Dimer value is more than 5000 ng/mL (ORa 7.8; IC95% 4.09-14.92). Conclusion: D-Dimer is an independent factor that is associated with PE in patients with COVID - 19 in critical care, especially if the value is over 5000 ng/mL.