Schools are scenarios for detection of mental problems and promotion of well-being. It is necessary to create intercultural processes that better respond to these needs. The objective of the present study was to collaboratively construct a route for the detection of mental health problems from the school environment from the Colombian Amazon. Nine focus groups were carried out, each made up of nine people, health professionals and ethnoeducators. The strengthening of one's own culture is highlighted, such as the use of fishing and agriculture. The starting point of this process is the development of a pathway that defines roles to play in the support of specific cases of school mental health care with an ethnic focus. Intercultural school mental health calls for strengthening one's own culture as a protective factor for mental health, which involves understanding aspects of the culture by those working with children and youth in the region.