The tendency for Afro-descendant individuals with hypertension to retain salt and water can lead to low-renin hypertension. Different mutations have been described that give rise to a gain of function of the epithelial sodium channel (ENaC) and eventually Liddle syndrome. Furthermore, functional variant T8590C, located in the CYP4A11 gene which regulates salt and water homeostasis at multiple sites within the kidney, has been associated with hypertension. In order to evaluate these mutations, a prevalence study was conducted.