This dataset accompanies the manuscript:<br> "Networks and genes modulated by posterior hypothalamic stimulation in patients with aggressive behaviours: Analysis of probabilistic mapping, normative connectomics, and atlas-derived transcriptomics of the largest international multi-centre dataset."<br> DOI: (https://doi.org/10.1101/2022.10.29.22281666) by Flavia Venetucci Gouveia1,2,3*†,Jürgen Germann4,5†, Gavin JB Elias4,5, Alexandre Boutet4,6, Aaron Loh4,5, Adriana Lucia Lopez Rios7,8, Cristina V Torres Diaz9, William Omar Contreras Lopez10,11, Raquel CR Martinez3,12, Erich T Fonoff13, Juan C Benedetti-Isaac14, Peter Giacobbe 2,15,16, Pablo M Arango Pava17, Han Yan5,18, George M Ibrahim5, 18,19,20, Nir Lipsman2,5,15, Andres M Lozano4,5, Clement Hamani2,5,15* 1. Neuroscience and Mental Health, Hospital for Sick Children Research Institute; Toronto, Canada <br> 2. Sunnybrook Research Institute; Toronto, Canada<br> 3. Division of Neuroscience, Sírio-Libanês Hospital; São Paulo, Brazil<br> 4. Division of Neurosurgery, Department of Surgery, University Health Network, Toronto, Canada<br> 5. Division of Neurosurgery, Department of Surgery, University of Toronto; Toronto, Canada<br> 6. Joint Department of Medical Imaging, University of Toronto; Toronto, Canada<br> 7. Department of Functional and Stereotactic Neurosurgery, University Hospital San Vicente Fundación,<br> Medellín, Colombia<br> 8. Department of Functional and Stereotactic Neurosurgery, San Vicente Fundación, Rionegro, Colombia<br> 9. Department of Neurosurgery, University Hospital La Princesa; Madrid, Spain<br> 10. Nemod Research Group, Universidad Autónoma de Bucaramanga; Bucaramanga, Colombia<br> 11. Division of Functional Neurosurgery, Department of Neurosurgery, FOSCAL Clinic; Bucaramanga,<br> Colombia<br> 12. LIM 23, Institute of Psychiatry, School of Medicine, University of São Paulo; São Paulo, Brazil<br> 13. Department of Neurology, Integrated Clinic of Neuroscience, School of Medicine, University of São Paulo;<br> São Paulo, Brazil.<br> 14. Stereotactic and Functional Neurosurgery Division of the International Misericordia Clinic; Barranquilla,<br> Colombia<br> 15. Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre; Toronto, Canada<br> 16. Department of Psychiatry, University of Toronto; Toronto, Canada<br> 17. Servicio de Neuocirugia Funcional y Esterotaxia, Clinica Comuneros Bucaramanga, Clinica Desa y Clinica<br> Dime Neurocardiovascular de Cali; Clinica Nueva del Lago, Bogota, Colombia.<br> 18. Division of Neurosurgery, The Hospital for Sick Children; Toronto, Canada<br> 19. Institute of Biomedical Engineering, University of Toronto; Toronto, Canada<br> 20. Institute of Medical Science, University of Toronto; Toronto, Canada<br> † Flavia Venetucci Gouveia and Jürgen Germann contributed equally to this work and share first authorship. * Corresponding Author: Dr. Flavia Venetucci Gouveia. Neuroscience and Mental Health, Hospital for Sick Children Research Institute. 686, Bay Street, Toronto, ON, M5G 0A4, Canada. flavia.venetuccigouveia@sickkids.ca<br> * Corresponding Author: Dr. Clement Hamani. Sunnybrook Research Institute. 2075 Bayview Ave, S126. Toronto, ON, M4N3M5, Canada. clement.hamani@sunnybrook.ca It contains a zip folder ("estimated_binary_Volume_of_Tissue_Activated.zip") with one file (in nii.gz format) per patient estimating the Volume of Activated Tissue for that patient (the estimated 'reach' of the active DBS stimulation) and a demographics file.<br> The case numbers are identical to Table 1 in the manuscript.