The COVID-19 pandemic has caused effects on the psychological well-being of adolescents, which translates into significant levels of stress; in view of this, it is important to identify the psychological resources to cope with it. The objective of this study was to determine the relationship between the level of perceived stress and the psychological coping strategies employed by adolescents in school during the pandemic. A total of 98 students, aged 12 to 20 years, from 7 urban and rural educational institutions in Nariño, Colombia, participated in the study; The Coping Strategies Scale - Modified, the Perceived Stress Scale, and a sociodemographic questionnaire were administered online. A group comparison analysis (t for Student), a Spearman correlation analysis, and a multiple linear regression model were performed. The correlation results show that stress was positively related to the strategies: waiting (.216), emotional avoidance (.396), aggressive reaction (.532), and expression of coping difficulty (.405); and negatively related to: problem-solving (-.487), seeking social support (-.340), religion (-.237), and positive re-evaluation (-.476). The strategies of problem-solving, aggressive reaction, and expression of coping difficulty were able to predict 57% of the variability of stress level. Adolescents used passive, or emotion-focused, coping strategies when experiencing elevated levels of stress, some of which may be considered predictors of stress.