In recent years, there has been an increase in the diagnosis of lung cancer (LC) in women, who, according to some reports, suffer from a high prevalence of sexual dysfunction (SD) associated with oncological treatments. Our aim was to describe the characteristics and risk factors for SD in a cohort of Spanish women with LC. Analytical observational study with women included in the CLARIFY H2020 project at the Hospital Universitario Puerta de Hierro. From October 2020 to March 2023, clinical and demographic variables were collected as well as measures of sexual function using a validated Spanish-language, gender-targeted questionnaire. The frequency of sexual activity and the performance of the phases of sexual response were evaluated. Descriptive and logistic regression analyses were conducted. The overall project included 383 patients. Of these, 36.8% (141) had lung cancer and 45.4% (64) were women. 45% (30) of the men vs 36.2% (21) of the women with LC reported being sexually active. The characteristics of female population in the table. Severe dysfunction of most phases of sexual response was reported in 34-60% of women. Statistically significant associations were found in age ≥65 years OR 2.18 p0.04 (95% CI 1.01-4.7) and female gender OR 3.62 p 0.03 (95% CI 1.55-8.5) with dissatisfaction with sexual performance as well as female gender OR 3.45 p 0.004 (95% CI 1.48-8.03) and age ≥65 years OR 2.04 p 0.06 (95% CI 1.48-8.03) with severe orgasm disorder.Table: 252PCharacteristics of women with LC included in CLARIFY project% N 64Mean age63 years (range 44-85)Tumoral stageEarly53%(33)Metastatic47%(30)Marital statusMarried75%(48)Separated/Divorced14%(9)Single5%(3)Educational levelUniversity38%(24)Intermediate20%(13)Basic2%(1)No education40%(26)Time from diagnosis≥ 5 years26.6%(17)2-4 years60.9%(39)<1 year12.5%(7)Global sexual dissatisfaction according to treatment and tumoral stageImmunotherapy56%(9)Chemotherapy68%(11)Chemo immunotherapy50%(3)Follow up100%(6)Targeted therapy42%(8)Early65%(21)Metastatic30%(9) Open table in a new tab In our study, women with LC are at high risk of developing sexual dysfunction associated with oncologic treatment. It is necessary to screen and diagnose this disorder early and to offer multidisciplinary support to this population (Table).