Abstract The objectives of the proposed paper are to investigate the effectiveness of NanoRPM, a nanotechnology-based solution, in controlling water production in Colombian hydrocarbon reservoirs. The scope of the paper includes evaluating the adsorption capacity and durability of NanoRPM compared to conventional RPM, as well as assessing its performance under static and dynamic conditions. Additionally, the field pilot results will be analyzed to confirm the viability and long-term effectiveness of NanoRPM for water control in reservoirs. The study evaluated the efficacy of NanoRPM, a nanotechnology-based solution, in reducing water production in Colombian hydrocarbon reservoirs. Experimental tests, including fluid-fluid and rock-fluid interaction tests under various conditions, were conducted. Specific factors of the Eastern Llanos Basin were considered. The adsorption capacity and durability of NanoRPM were compared to conventional RPM. The findings were aligned with field pilot results to validate NanoRPM's effectiveness in mitigating water production and ensuring long-term performance. The study found that NanoRPM showed exceptional performance in controlling water production in Colombian hydrocarbon reservoirs. It exhibited six times greater adsorption capacity than conventional RPM under static and dynamic conditions. These results were consistent with the field pilot data, which demonstrated a significant 15% reduction in water production over an eighteen-month period. The high surface area-to-volume ratio of NanoRPM was identified as a key factor contributing to its improved adsorption on rock surfaces. Additionally, NanoRPM exhibited superior durability in the porous medium compared to conventional RPM, indicating its long-term effectiveness in water control. Consequently, the study concluded that NanoRPM is a technically viable and durable solution for addressing water control challenges in hydrocarbon reservoirs. The findings offer valuable insights into the application of nanotechnology in reservoir engineering and water management strategies, presenting a promising approach to reducing water-related costs in mature Colombian fields. This paper presents novel information by exploring the use of NanoRPM, a nanotechnology-based solution, for water control in Colombian hydrocarbon reservoirs. The study provides new insights into the effectiveness of NanoRPM compared to conventional RPM, showcasing its exceptional adsorption capacity and durability. The findings contribute to the existing body of literature by offering a promising technological advancement in mitigating water production and reducing associated costs in the petroleum industry.