Transorbital brain injuries (TOBIs) due to penetrating foreign bodies are relatively rare and represent a unique type of trauma because of the different kinds of objects, mechanisms, trajectories, and structures that can be compromised. The diagnosis of TOBI requires a high degree of suspicion, thorough clinical examination, and appropriate imaging to characterize the presence of damage. The treatment options described in the literature include conservative and surgical approaches, with little evidence of their effectiveness and superiority; therefore, patient management must be individualized. We report our consecutive case series of TOBI describing the penetrating foreign body, traumatic path, surgical approach, intraoperative findings, outcomes, and complications. We also review the available literature.