Physiological resilience is acquired according to the individual's capacity to adapt to stress.The aim of this article is to describe the factors that influence resilience in older adults.This is a narrative review based on a database search (PubMed and BVS) with MeSH and DeCS descriptors and keywords such as: resilience, physiological resilience and older adults.Of the 67 initial articles, 23 met the inclusion criteria for analysis and 10 were selected.The individual exposome influences changes in the epigenome, allowing a differential response to the allostatic load and access to active aging that can be modified through early and lasting interventions in older adults to impact on improved quality of life.Modifiable and multidomain contributors to resilience (intrinsic and extrinsic) are the key to its enrichment and contribute to a successful aging process in older adults.