This work presents results of the synthesis of mixed metal oxides such as calcium ferrite by dissolving Ca(NO 3 ) 2 .4H 2 O, Fe(NO 3 ) 3 .9H 2 O and NH 4 OH with constant stirring, and assisted with conventional heating or microwave (MAE) combustion. using natural aloe vera extract as fuel at 900°C for 3 hours. The resulting material was characterized by instrumental methods for powders. Calcium ferrite powders were used for the modification of the surface of a glassy carbon electrode. The modified electrodes were used for the electrochemical investigation of acetaminophen (ACe) and acyclovir (ACy), at controlled pH. The preliminary results demonstrated the potential application of calcium ferrite powders in the electrochemical detection of molecules of pharmaceutical interest.