Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare skin condition typified by extracellular dermal deposition of amyloid proteins derived from immunoglobulin light chain L protein released by a localized infiltrate of plasma cells.It usually presents as solitary or multiple asymptomatic nodular lesions and its progression to systematic Figure 1 Pink-brown nodules and papules on the left leg (a).Polarized-light dermoscopy shows a diffuse Orange structureless, along with linear-curved vessels and purpuric (hemorrhagic) globules (arrow) (b).Histology shows deposition of pale eosinophilic amorphous substance in the superficial dermis (c) and hemorrhagic infiltrates at the dermo-hypodermal border (d); H&E x100.Positive staining for Congo red (e) and green apple birefringence under polarized light (f); x200.
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Amyloidosis: Diagnosis, Treatment, Outcomes
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FuenteClinical Cosmetic and Investigational Dermatology