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Dermoscopy of Primary Localized Cutaneous Nodular Amyloidosis

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Abstract:

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare skin condition typified by extracellular dermal deposition of amyloid proteins derived from immunoglobulin light chain L protein released by a localized infiltrate of plasma cells.It usually presents as solitary or multiple asymptomatic nodular lesions and its progression to systematic Figure 1 Pink-brown nodules and papules on the left leg (a).Polarized-light dermoscopy shows a diffuse Orange structureless, along with linear-curved vessels and purpuric (hemorrhagic) globules (arrow) (b).Histology shows deposition of pale eosinophilic amorphous substance in the superficial dermis (c) and hemorrhagic infiltrates at the dermo-hypodermal border (d); H&E x100.Positive staining for Congo red (e) and green apple birefringence under polarized light (f); x200.

Tópico:

Amyloidosis: Diagnosis, Treatment, Outcomes

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Información de la Fuente:

SCImago Journal & Country Rank
FuenteClinical Cosmetic and Investigational Dermatology
Cuartil año de publicaciónNo disponible
VolumenVolume 17
IssueNo disponible
Páginas395 - 398
pISSNNo disponible
ISSNNo disponible

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