The article presents the methodology used by the Colombia Consortium to negotiate the first transformative agreements (TAs) in Latin America. These TAs are a strategy to manage costs associated with Article Processing Charges (APCs), facilitate the transition to Open Access (OA) and increase the visibility of Colombian publications. The road map for the design of TAs in Colombia is based on a methodology that considers both qualitative and quantitative aspects, with a key element being the analyses the scientific publication trends in Colombian institutions. This methodological route allowed the Colombia Consortium to sign with three commercial publishers.