Objective: This study aimed to elucidate the clinical features of febrile seizures (FS) in COVID-19 patients and compare them according to variants.Methods: A total of 730 patients with FS were divided into the COVID-19 positive group (wild, alpha, delta, omicron variant) and the COVID-19 negative group (control group).Results: The study analysed 132 patients in the COVID-19 group and 570 patients in the non-COVID-19 group. The Omicron variant period had the highest frequency of FS (p<0.001). Children with COVID-19 experienced FS at a later onset. A negative correlation was found between sodium levels below 135 mmol/L and FS in patients with COVID-19 infection (r = -0.2669, p<0.001). The study identified a significant negative correlation (r = -0.2578, p <0.001) between the age of COVID-19 positive patients with febrile seizures and sodium variables during the wild and omicron variant periods. The long-term follow-up of patients with febrile seizures revealed that COVID-19 infection did not affect the development of epilepsy.Conclusion: Febrile seizures appear to be more common in COVID-19 patients during the Omicron variant period. Our study found that hyponatremia is a risk factor for febrile seizures in patients over 48 months of age, both in the wild period and the Omicron variant period. Although our study revealed a significant association between low sodium levels and age, the pathogenesis of febrile seizures in patients remains unclear. In a long-term follow-up study of patients with febrile seizures, the development of epilepsy was not found to be correlated with COVID-19 infection.