Intraarticular and intraosseous injections of platelet rich plasma combined with hyaluronic acid for knee osteoarthritis Palabras clave: osteoartrosis de la rodilla, plasma rico en factores de crecimiento, factores de crecimiento, infiltración intraósea, ácido hialurónico, infiltración intraarticular.20.20 and the post-operative mean was 22.81 ± 17.25 (p < 0.001).The pre-operative and post-operative mean of the VAS scores were 5.79 ± 2.01 and 2.41 ± 1.43 (p < 0.001), respectively.The largest improvement in WOMAC (from 42.86 to 13.69) was observed in the youngest patients (44 to 55 years old) and the largest reduction in VAS (from 6.89 to 2.22) was seen in patients aged 56 to 70 years.Conclusion: the combination of IO and IA plasma rich in growth factor (PRGF) treatment with the IA-HA treatment yielded excellent results, diminishing pain and improving motor functionality in patients with KOA.