Long-term orthodontic treatment may be associated with increased risk of bone necrosis, root resorption, caries, and loss of patient motivation. Accelerating orthodontic tooth movement (OTM) is desirable for patients and dentists. Recent investigations focused on accelerating OTM by physical, chemical or surgical techniques. Corticotomy and osteotomy accelerates OTM while non-surgical methods showed variable rate of success. The purpose of this systematic review is to evaluate the efficacy of non-surgical methods to accelerate OTM.Materials and methodsLiterature search was performed on MEDLINE, EMBASE and CENTRAL databases up to January 2023. Inclusion criteria were randomized clinical trials (RCT); fixed orthodontics and non-surgical methods used to accelerate OTM. Cochrane Collaboration’s tool Version 2 was used for assessing risk of bias of RCT. The primary outcomes evaluated were time, amount, and rate of displacement. Adverse effects were evaluated as secondary outcomes. Prospero registration number CRD42018117564.ResultsLiterature research identified 883 articles; after screening of titles, abstracts, and full-text studies; 30 fulfilled the inclusion criteria and were included. 16 of the 30 studies investigated the effect of LLLT; ten studies investigated SW; one study reviewed the influence of VitD3, and one study analyzed the effects of Platelet-rich plasma (PRP) and Platelet-rich fibrin (PRF). LLLT speeds-up 25 days the canine retraction and local administration of VitD3 potentiate OTM. No difference in efficacy was found between the use of PRP and PRF or shock waves (SW). None reported adverse effects related to the therapies.ConclusionsBased on current information from individual studies outcomes and the pooled estimates, weak evidence suggests that intraoral LLLT speeds-up 25 days the canine retraction and that local administration of VitD3 potentiate OTM, compared to conventional orthodontics. The use of PRP and SW showed inconsistent results accelerating the OTM.