This paper examines the relationship among Research and Development (R&D) expenditure, government effectiveness, and voice accountability in 15 Latin American countries. R&D expenditure is a crucial driver of innovation and economic growth, and effective governance and voice accountability are essential for promoting transparency and citizen participation in decision-making processes. The study utilizes a panel dataset from 2002 to 2021 and employs computer data analysis to estimate the effects of changes in government effectiveness and voice accountability on R&D expenditure. The findings reveal a positive impact of government effectiveness and voice accountability on R&D expenditure. A 1% increase in government effectiveness is associated with a 0.618% increase in research development expenditure, while a 1% rise in voice accountability corresponds to a 0.625% increase. These results highlight the importance of effective governance and citizen engagement in fostering R&D investment.