Difficulties maintaining work-life balance have intensified in recent decades. Factors such as the emergence of new information technologies, cultural changes in attitudes towards the relationship between work and family, and the great diversity of family structures have led people to experience higher levels of tension, which derive in a greater feeling of emotional exhaustion and a reduction in job performance levels. Given this, many studies are focusing their attention on the development of individual strategies when regulating the interference between these factors. The objective of this study was to verify the possible modulating effect of a personal resource such as resilience, in the influence of work-family balance on emotional exhaustion and the perception of performance of employees in Public Administration. Data were collected from 315 employees of a Spanish public university. The results confirm the effect of total modulation that transforms the influence of work-family balance on emotional exhaustion into a significant and negative one (direct effect: .599, ns; modulated effect -.182) and on intra-role performance (effect modulated mediation -.034). The results of the Johnson-Newman method reveal that it is from the value 4.25 in the resilience values ​​on a scale between 1 and 5, when the sign of the relationship changes significantly. It concludes with a discussion of the practical implications of the study, along with limitations and suggestions for future research.