The replacement of petroleum-based plastics with biodegradable materials emerges as a potential solution to the environmental issues caused by the constant consumption of non-degradable plastic materials.Polyhydroxyalkanoates (PHA) are natural biopolymers produced by several bacteria species as an evolutive mechanism to store carbon and energy.Among these PHA-producing bacteria, the Gram-negative bacterium Cupriavidus necator has been studied as the model organism for PHA production due to its high accumulation capacity (up to 90% of dry cell weight).Nevertheless, the large-scale production of those biopolymers is still limited by the production costs, especially regarding the carbon source, which may represent up to 50% of the total cost of the PHA production process.For this study, a bibliometric analysis was conducted to investigate the trends in PHA production studies by C. necator with an emphasis on the use of low-cost substrates, in addition to the perspectives for this emerging industry in Latin America as a continent with access to significant biomass resources, agroindustry products, and byproducts.The Scopus and the Web of Science databases were used for data collection, and a total of 532 and 2995 articles were identified for the period between 1992 and 2022, and between 2000 and 2022, respectively. ARTICLE HIGHLIGHTS •Bibliometric analysis of PHA production from low-cost substrates by C. necator was carried out. •Potential and available biomasses in LATAM are reported for PHA production. •The most commonly low-cost carbon sources used to production of PHA by C. necator are waste oils and fats, sugar-rich residues, and derivatives.