Abstract Background LatAm‐FINGERS is the first non‐pharmacological multicenter randomized clinical trial to prevent cognitive impairment in Latin America (LA). The trial congregates the effort of 12 Countries, including Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Dominican Republic, Ecuador, Mexico, Peru, Puerto Rico, and Uruguay. The main aim is to investigate the feasibility of a 24‐month multi‐domain lifestyle intervention and its efficacy on the cognition of 1200 participants. Method Recruitment strategies differed across countries and regions because they were adapted to the idiosyncrasies of the local populations. Recruitment from medical center databases was found insufficient to provide a diverse cohort. Alternative strategies included social media posts with infographics and videos. A novel and successful strategy was in‐person talks in local city halls and local nongovernmental organizations for older adults. The use of positive colloquial language was found to be much more effective in reaching underserved populations than scientific language (e.g., focusing on brain health vs. clinical trials). A significant recruitment source in low‐income regions of Peru, Bolivia, and Ecuador was the promotion within non‐Catholic religious organizations. Appealing to the religious leaders’ endorsement was crucial for generating trust and interest in different communities. In Mexico, one successful recruitment strategy involved performing physical exercises in local parks in low‐income neighborhoods to demonstrate the intervention in‐vivo, which attracted interested people from the area. Overall, in‐person contact with participants and time dedicated to explaining the trial’s rationale in lay language was the most important strategy. Result As of January 2023, we have enrolled 948 participants in the study. The mean (SD) age is 67.5 (4.8) years, 75% are female, the level of education is 12.6 (3.8) years, and the MMSE score is 27.3 (1.7). To date, 58% of the population self‐reports as mestizo (mixed race), and 28% as Caucasian. Other ethnicities represented include Native American (1.5%), Mulato (5%), Black (2%), Asian (0.7%), and other (5%). Conclusion The LatAm‐FINGERS trial recruited participants from a wide range of diverse populations. Our results support that using tailored and idiosyncratic strategies is decisive in reaching different communities and ensuring the representativeness of the study sample.