We thank Drs. Kleebayoon and Wiwanitki for their interest in our letter (1); we found here an excellent opportunity to discuss some additional thoughts from researchers with experience in this specific topic, which can contribute to further understand the monkeypox (Mpox) infection.Since the interaction through the journal provides an academic forum, we want to explore some topics mentioned by the authors in order to promote scientific discussion and improve the understanding of those topics.As the correspondence authors stated, there are other issues to consider with the aim of preventing the infection (2).Besides control measures, they raise an important point: the participation of experts who are familiar with the subject.According to a study concerning co-infections, practitioners need to be aware when evaluating patients with rectal signs and symptoms, that they should consider Mpox and the possibility of concurrent rectal sexually transmitted infections (STIs) (3).