BACKGROUND/AIMS:The aim of this study was to evaluate the effect of preoperative and postoperative music intervention on anxiety, perceived pain severity and patient comfort in patients undergoing retrograde intrarenal surgery (RIRS). MATERIALS AND METHODS:This prospective and quasi-experimental study included a total of 58 patients undergoing RIRS between May 14 th and December 31 st , 2019.The patients were divided into 2 groups.Group 1, the music intervention group, included 30 patients, and group 2, the control group, had 28 patients.The primary outcome of this study was anxiety levels and the secondary outcomes were pain severity and patient comfort.The visual analog scale-anxiety (VAS-A) was used to evaluate the patients' anxiety levels while the VAS was used for the evaluation of pain severity. RESULTS:A significant difference was found between the groups in terms of VAS-A scores measured in the preoperative and postoperative periods (p<0.001,p=0.024, respectively).In both measurements, the group 1 VAS-A score was significantly lower than group 2. When the postoperative VAS pain scores of patients were examined; pain severity in group 1 was lower compared to group 2 and significant difference was found between the groups (p=0.017).More patients in group 1 were found to feel in comfort than in the control (p=0.006). CONCLUSION:It was observed that music intervention during the preoperative and postoperative periods reduced pain, anxiety, and increased patient comfort in RIRS patients.For this reason, it is thought that it is appropriate to use music intervention in patients undergoing RIRS.