Post-cardiac injury syndrome is a type of inflammatory pericardial syndrome that occurs when there is some degree of direct or indirect injury to the pericardium or myocardium, and can occur in patients with acute myocardial infarction, trauma associated with cardiothoracic surgery and accidental or iatrogenic trauma associated with percutaneous coronary intervention. Its definition includes the terms postinfarction pericarditis, post traumatic pericarditis, and postpericardiotomy syndrome. Its pathogenesis is explained by an autoimmune response and a pleuropericardial inflammatory state triggered by tissue injury in the absence of infections or other etiologies. We present the case of a 31-year-old male patient who developed post-traumatic pericarditis secondary to chest trauma who had an adequate response to management with acetylsalicylic acid and did not develop complications.