Objective: In recent years, new developments have been incorporated into daily practice in the management of immune thrombotic thrombocytopenic purpura (iTTP).In particular, clinical scoring systems could help clinicians with clinical decision-making and early recognition.However, older patients frequently present with more organ involvement and in unusual ways.The ways in which age could affect these clinical prediction scoring systems remain unclear.We evaluated the use of PLASMIC and French scores in patients over 60 years of age. Materials and Methods:We performed a retrospective crosssectional analysis of patients over 60 years of age with a presumptive diagnosis of iTTP between 2014 and 2022 at 10 centers.We calculated PLASMIC and French scores and compared our data with a singlecenter analysis of younger patients presenting with thrombotic microangiopathy.Results: Our study included 30 patients over 60 years of age and a control group of 28 patients younger than 60 years.The diagnostic sensitivity and specificity of a French score of ≥1 were lower in older patients compared to the control group (78.9% vs. 100% and 18.2% vs. 57.1%,respectively).The diagnostic sensitivity and specificity of a PLASMIC score of ≥5 were 100% vs. 95% and 27.3% vs. 100% for the study group and control group, respectively.Our study showed a Amaç: Son yıllarda, immün trombotik trombositopenik purpura (iTTP) yönetiminde günlük uygulamalara yeni gelişmeler eklenmiştir.Özellikle klinik skorlama sistemleri klinisyenlere klinik karar verme ve erken tanıda yardımcı olabilir.Ancak, yaşlı hastalar genellikle daha fazla organ tutulumu ve alışılmadık şekillerde başvurabilmektedir.İleri yaşın bu klinik tahmin skorlama sistemleri üzerindeki etkisi belirsizdir.Bu bağlamda, PLASMIC ve French skorlarının 60 yaş ve üzeri