<h3>Background</h3> Damage to the cervical corticospinal tract (CST) leads to paralysis of the limbs and trunk. Fortasyn® Connect (FC) is a multi-nutrient that supports synapse formation and function. We hypothesised that FC will be neuroprotective and promote regeneration and neuroplasticity of the CST after cervical contusion SCI (CCSCI). <h3>Methods</h3> Following injury, 60 adult Sprague-Dawley rats were treated with either a control diet (n = 20), FC for 18 weeks followed by a control diet for 14 weeks (n = 20), or a control diet for 18 weeks then FC for 14 weeks (n = 20). At 30 weeks, biotinylated dextran amine (BDA) was injected into the motor cortex contralateral to the lesion. The injured sections from animals with left-sided lesions were processed with toluidine blue or BDA staining (n = 5 to 7). <h3>Results</h3> In this model, FC treatment did not affect neuronal survival, lesion size, or cavitation. However, the acute treatment group showed increased sparing of the CST and both treatment groups demonstrated increased CST sprouting into grey matter. <h3>Conclusion</h3> While FC was not notably neuroprotective in this CCSCI model, it significantly promoted CST reorganisation, suggesting that FC can modulate neuroplasticity following cervical contusion SCI, even with delayed treatment.