Abstract Glucagon is a hormone released from the alpha cells of the pancreas. It has a major role in carbohydrate metabolism. It has a major role in increasing blood glucose levels and is helpful in glycogenolysis, gluconeogenesis, and amino acid catabolism. Its role in lipid metabolism is in the form of lipolysis and beta-oxidation of fatty acids. It also has major implications in the pathogenesis of metabolic dysfunction-associated steatotic liver diseases or non-alcoholic fatty liver disease.