Abstract Background: Orthognathic surgery (OS) is used to correct facial asymmetry, dentofacial deformity, skeletal malocclusion, and in complementary procedures to improve mastication and aesthetics. Herewith we report the case of a patient with progressive facial asymmetry who underwent OS with virtual surgical planning, patient-specific guides and custom implants at the Colsanitas Clinic, Bogota, Colombia. Case presentation: Twenty-four-year-old female with a dentofacial deformity secondary to condylar hyperplasia of 9 years evolution. A hybrid technique combined surgical planning and 3D printing of the customized guides and miniplates following a “surgery first” approach. Conclusion: Orthognathic surgery with a hybrid technique resulted in a precise translation of the treatment plan with optimal functional and aesthetic outcomes and patient satisfaction.