COVID-19 had a negative impact on all areas of human development. In this chapter, we analyze Colombian children and adolescents' perception of health and well-being due to the COVID-19 pandemic in the context of widespread social isolation and fear. A total of 459 children of both genders, between the ages of 8 and 18, from public and private schools, participated. Children's perceptions and quality of life during the pandemic were measured. There was a significant correlation between health and well-being. Health was directly influenced by age, fear, mood, and sleep habits. Well-being was affected by relationships with parents, social support, and the school environment.