This paper opens the black box of policy co-production processes presented by the Colombian and Ecuadorian governments, regarding the traditional knowledge associated with genetic resources, in keeping with the necessities of Indigenous peoples. The purpose of this paper is to analyze what similarities and differences there exist in the role of the Ecuadorian and Colombian States as organizers, guarantors of plural expression, and facilitators of public deliberation, and how policymakers have opened the space for Indigenous peoples for producing traditional knowledge policy. The paper turns to qualitative research focused on collecting information from public actors. The data obtained assesses our working hypothesis that the role of the State in the production of traditional knowledge policy has been more democratic in Ecuador than in Colombia.