Autoimmune complications such as autoimmune hemolytic anemia (AIHA), an uncommon entity in pediatric patients, have been associated with infectious diseases.Knowledge of the pathophysiological mechanisms that contribute to the immune dysregulation caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection is highly important, and clarifying the hypotheses about the molecular mimicry linked to these complications is essential to overcome potentially life-threatening hematologic manifestations in the underestimated pediatric population during the pandemic.A 10-month-old male with respiratory and gastrointestinal symptoms due to a SARS-CoV-2 infection documented by a molecular biology test developed severe anemia symptoms with an autoimmune hemolytic etiology.Management with corticosteroids improved his clinical condition and hematologic parameters.AIHA is a pathology with a broad presentation spectrum.Many illnesses are associated with triggers of AIHA; however, only a few related to Coronavirus disease-2019 (COVID-19) in infants have been described.This case report reminds us to consider the AIHA condition as a possible complication of COVID-19 in children under five years old.