In this work, the enzymatic modification process of the cellulose obtained from the cocoa pod husk (CPH) Theobroma cacao L. Clone CCN51 was carried out. Physicochemical analyses such as pH, ethereal extract, ash, moisture, crude fiber, and water retention were carried out in order to characterize the material obtained and compare it with commercial cellulose, establishing the structural and physicochemical differences that occurred during the modification process. The results revealed that in the transformation process of the raw material by the action of the Celluclast 1.5 L enzyme, a yield of 29% was obtained, likewise, it was evidenced that there are significant differences in the characterization tests carried out between the commercial cellulose and the cellulose of the modified CPH Theobroma cacao L. clone CCN51.